منابع مشابه
microRNAs: Runts of the Genome Assert Themselves
microRNAs form an abundant class of 21–22 nucleotide, non-coding RNA that is common to diverse species of multicellular life. Although they are currently the subject of intense, directed study, the path toward their discovery has been dominated by chance and serendipity. In this review, I examine how these tiny molecules have risen from genetic obscurity to scientific stardom, and discuss the e...
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Work on reeection has frequently concentrated on programming languages and operating systems. This work either involves the use of tower reeection or meta-object protocols. The subject of this paper is a diierent form of reeection that is, we believe, more powerful and fundamental than the other kinds. Self modelling is a process that has not received attention in the literature; indeed, we bel...
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In eukaryotic cells, mRNAs are transcribed in the nucleus and must then be exported across the nuclear envelope before they can be translated in the cytoplasm. Multiple factors bind to nuclear mRNAs and mediate their translocation through the nuclear pores, but it is diffi cult to observe the rapid export of individual RNA molecules in real time. Two papers now track the movements of single mRN...
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In standard models with asymmetric information, the parties involved are assumed to have private information about their own characteristics. In the health insurance market, for example, customers are typically assumed to know more about their health status than insurers do, and if the customers use this information in deciding whether to buy insurance, we have a classic case of adverse selecti...
متن کاملSilent RNAs express themselves
R NA molecules stowed in cytoplasmic granules are generally thought to be silent. But a protein mutated in some amyotrophic lateral sclerosis (ALS) patients forms granules that permit translation of stored RNAs, Yasuda et al. reveal (1). The fi nding identifi es a new mechanism that could contribute to the pathology of the disease and suggests that RNAs in other types of granules also may not b...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2012
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.112.281014